Increased oxidative stress and anaerobic energy release, but blunted Thr-AMPK phosphorylation, in response to sprint exercise in severe acute hypoxia in humans
نویسندگان
چکیده
David Morales-Alamo, Jesús Gustavo Ponce-González, Amelia Guadalupe-Grau, Lorena Rodríguez-García, Alfredo Santana, Maria Roser Cusso, Mario Guerrero, Borja Guerra, Cecilia Dorado, and José A. L. Calbet Department of Physical Education, University of Las Palmas de Gran Canaria (Campus Universitario de Tafira), Las Palmas de Gran Canaria, Spain; Genetic Unit, Chilhood Hospital-Materno Infantil de Las Palmas, Avenida Marítima, Las Palmas de Gran Canaria, Spain; Research Unit, Hospital de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain; and 4 Department of Physiological Sciences I, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
منابع مشابه
Increased oxidative stress and anaerobic energy release, but blunted Thr172-AMPKα phosphorylation, in response to sprint exercise in severe acute hypoxia in humans.
AMP-activated protein kinase (AMPK) is a major mediator of the exercise response and a molecular target to improve insulin sensitivity. To determine if the anaerobic component of the exercise response, which is exaggerated when sprint is performed in severe acute hypoxia, influences sprint exercise-elicited Thr(172)-AMPKα phosphorylation, 10 volunteers performed a single 30-s sprint (Wingate te...
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The extremely high energy demand elicited by sprint exercise is satisfied by an increase in O2 consumption combined with a high glycolytic rate, leading to a marked lactate accumulation, increased AMP-to-ATP ratio, and reduced NAD(+)/NADH.H(+) and muscle pH, which are accompanied by marked Thr(172) AMP-activated protein kinase (AMPK)-α phosphorylation during the recovery period by a mechanism n...
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Compared to normoxia, during sprint exercise in severe acute hypoxia the glycolytic rate is increased leading to greater lactate accumulation, acidification, and oxidative stress. To determine the role played by pyruvate dehydrogenase (PDH) activation and reactive nitrogen and oxygen species (RNOS) in muscle lactate accumulation, nine volunteers performed a single 30-s sprint (Wingate test) on ...
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The aim of this study was to evaluate the effects of severe acute hypoxia on exercise performance and metabolism during 30-s Wingate tests. Five endurance- (E) and five sprint- (S) trained track cyclists from the Spanish National Team performed 30-s Wingate tests in normoxia and hypoxia (inspired O(2) fraction = 0.10). Oxygen deficit was estimated from submaximal cycling economy tests by use of...
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